| 报告题目： |
Structural-elastic determination of the lifetime of biomolecules under force |
| 报告人： |
Jie Yan |
| 报告人单位： |
Department of Physics and Mechanobiology Institute, National University of Singapore |
| 报告时间： |
2017年10月27日上午10:00 |
| 报告地点： |
科技楼南501会议室 |
| 报告摘要： |
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Several recent experiments have suggested that the structural-elastic properties of the native and the transition states of biomolecules are a key determinant of their mechanical stability. However, most of the current theoretical models were derived based on conformation diffusion of the molecule along a phenomenological energy surface, lacking a direct relation to the structural-elastic parameters of the molecules. Here, based on the Arrhenius law and taking into consideration of the structural-elastic properties of the native state and the transition state, we derived a simple analytical expression for the force-dependent lifetime of the native state of the molecules. We show that this model is able to fit a wide scope of experiments, and explain a variety of complex force-dependent transition kinetics observed in recent experiments. The results highlight a previously largely unrecognized structural-elastic determinant of the lifetime of biomolecules under force, and provide a new theoretical framework that can inform us the structural-elastic properties of the molecules.
Sketch of the structure of a protein domain in the native and transition states.
References
1. Chen, H. et al. (2015). “Dynamics of equilibrium folding and unfolding transitions of titin immunoglobulin domain under constant forces.” Journal of the American Chemical Society. 137: pp 3540–3546.
2. Yao, M. et al. (2016). "The mechanical response of talin." Nature Communications, 7: 11966.
3. Yuan, G. et al. (2017). “Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains.” Angewandte Chemie, 129: 5582-5585.
4. Guo, S. et al. (2017). " Structural-elastic determination of the lifetime of biomolecules under force." Under review.
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| 报告人简介： |
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Jie Yan is currently a professor in the department of physics and a principal investigator in the Mechanobiology Institute, National University of Singapore. He is also a Fellow of American Physical Society and a Singapore NRF Investigator. Using single-molecule appraoch, his research aims to provide insights of the molecular mechanisms underlying a broad spectrum of biological areas such as mechanobilology, chromosome organization and DNA damage repair.
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